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UAMS
Institute on
Aging
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Original Research Publications
Supported by the Neuropathology Core
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Griffin WST, Sheng JG, Roberts GW, Mrak RE.; Interleukin-1 expression in different plaque types
in Alzheimer's disease: significance in plaque evolution. J Neuropathol Exp Neurol 1995;54:276-281.
- Griffin WST, Sheng JG, Royston MC, Gentleman SM, McKenzie JE, Graham DI, Roberts GW, Mrak RE.;
Glial-neuronal interactions in Alzheimer's disease: the potential role of a 'cytokine cycle'
in disease progression. Brain Pathol 1998;8: 65-72.
- Griffin WST, Sheng JG, McKenzie JE, Royston MC, Gentleman SM, Brumback RA, Cork LC, Del Bigio MR,
Roberts GW, Mrak RE.; Life-long overexpression of S100beta in Down's syndrome: Implications for Alzheimer
pathogenesis. Neurobiol Aging 1998;19:401-405.
- Griffin WST, Sheng JG, Gentleman SM, Graham DI, Mrak RE, Roberts GW.; Microglial interleukin-1
a expression in human head injury: correlations with neuronal and neuritic
beta-amyloid precursor protein expression. Neurosci Lett 1994;176:133-136.
- Griffin WST, Sheng JG, Mrak RE.; Senescence-accelerated overexpression of S100beta in brain of SAMP6 mice.
Neurobiol Aging 1998;19:71-76.
- Griffin WST, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, White CL, III, Araoz C.; Brain
interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad
Sci USA 1989;86:7611-7615.
- Griffin WST, Yeralan O, Sheng JG, Boop FA, Mrak RE, Rovnaghi CR, Burnett BA, Feoktistova A, Van Eldik LJ.;
Overexpression of the neurotrophic cytokine S100beta in human temporal lobe epilepsy.
J Neurochem 1995;65:228-233.
- Grimaldi LM, Casadei VM, Ferri C, Veglia F, Licastro F, Annoni G, Biunno I, De Bellis G, Sorbi S, Mariani C,
Canal N, Griffin WS, Franceschi M.; Association of early-onset Alzheimer's disease with an interleukin-1a
gene polymorphism. Ann Neurol 2000;47:361-5.
- Ito K, Ishikawa Y, Skinner RD, Mrak RE, Morrison-Bogorad M, Mukawa J, Griffin WST.;
Lesioning of the inferior olive using a ventral surgical approach: characterization of temporal and spatial
responses at the lesion site and in cerebellum. Molec Chemical Neuropathol 1997;31: 245-264.
- Li Y, Barger, SW, Liu L, Mrak RE, Griffin WST.; S100beta induction of the pro-inflammatory cytokine
interleukin-6 in neurons: Implications for Alzheimer pathogenesis. J Neurochem 2000;74:143-150.
- Li Y, Liu L,
Barger SW, Mrak RE, Griffin WST: Vitamin E suppression of
microglial activation is neuroprotective. J Neurosci Res
66:163-170, 2001.
- Li Y, Liu L, Kang J, Sheng JG, Barger SW, Mrak RE, Griffin WST.; Neuronal-glial
interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase
activity and mRNA expression. J Neurosci 2000;20:149-155.
- Li Y, Liu L,
Liu D, Woodward S, Barger SW, Mrak RE, Griffin WST: Microglial
activation by uptake of fDNA via a scavenger receptor. J
Neuroimmunol 147:50B55,
2004.
- Li YK, Wang J, Sheng JG, Liu L, Barger SW, Jones RA, Van Eldik, LJ, Mrak RE, Griffin WST.;
S100beta increases levels of beta-amyloid precursor protein and its encoding mRNA in rat neuronal cultures.
J Neurochem 1998;71:1421-1428.
- Marshak DR, Pesce SA, Stanley LC, Griffin WST.; Increased S100 neurotrophic activity in Alzheimer disease
temporal lobe. Neurobiol Aging 1992;13:1-7.
- Mrak RE, Sheng JG, Griffin WST.; Correlation of astrocytic S100beta expression
with dystrophic neurites in amyloid plaques of Alzheimer's disease. J Neuropathol Exp Neurol
1996;55: 273-279.
- Nicoll JA, Mrak RE, Graham DI, Stewart J, Wilcock G, MacGowan S, Esiri MM, Murray LS, Dewar D,
Love S, Moss T, Griffin WST.; Association of interleukin-1 gene polymorphisms with Alzheimer's disease.
Ann Neurol 2000;47:365-8.
- Royston MC, McKenzie J, Gentleman SM, Sheng JG, Mann DMA, Griffin WST, Mrak RE.;
Overexpression of the neuritotrophic cytokine S100beta in Down's syndrome: correlation with patient age
and beta-amyloid deposition. Neuropathol Applied Neurobiol 1999;25:387-393.
- Sheng JG, Boop FA, Mrak RE, Griffin WST.; Increased neuronal beta-amyloid precursor protein expression
in human temporal lobe epilepsy: association with interleukin-1a
immunoreactivity. J Neurochem 1994;63:1872-9.
- Sheng JG, Griffin WST, Royston CM, Mrak RE.; Distribution of IL-1-immunoreactive microglia in
cerebral cortical layers: Implications for neuritic plaque formation in Alzheimer’s disease.
Neuropathol Appl Neurobiol 1998;24:278-83.
- Sheng JG, Ito K, Skinner RD, Mrak RE, Rovnaghi CR, Van Eldik LJ, Griffin WST.;
In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving
force in Alzheimer pathogenesis. Neurobiol Aging 1996;17:761-766.
- Sheng JG,
Jones RA, Zhou XQ, McGinness JM, Van Eldik LJ, Mrak RE, Griffin WST:
Interleukin-1 promotion of MAPK-p38 overexpression in experimental
animals and in Alzheimer=s
disease: potential significance for tau protein phosphorylation.
Neurochem Int 39:341-348, 2001.
- Sheng JG, Mrak RE, Bales KR, Cordell B, Paul SM, Jones RA, Woodward S, Zhou XQ, McGinness
JM, Griffin WST.; Overexpression of the neuritotrophic cytokine S100beta precedes the
appearance of neuritic beta-amyloid plaques in APPV717F mice. J Neurochem 2000;74:295-301.
- Sheng JG, Mrak RE, Griffin WST.; S100beta protein expression in Alzheimer disease: potential role in
the pathogenesis of neuritic plaques. J Neurosci Res 1994;39:398-404.
- Sheng JG, Mrak RE, Griffin WST.; Microglial interleukin-1a
expression in brain regions in Alzheimer's disease: Correlation with neuritic plaque distribution.
Neuropathol Appl Neurobiol 1995;21:290-301.
- Sheng JG, Mrak RE, Griffin WST.; Enlarged and phagocytic, but not primed,
IL-1a-immunoreactive microglia increase with age in normal human brain.Acta Neuropathol 1998;95:229-34.
- Sheng JG,
Mrak RE, Jones RA, Brewer MD, Zhou XQ, Mcginness J, Woodward S,
Bales K, Paul SM, Cordell B, Griffin WST: Neuronal DNA damage
correlates with overexpression of interleukin-1β converting enzyme
in APPV717F mice Neurobiol Aging 22:895-902, 2001.
- Sheng JG, Mrak RE, Rovnaghi CR, Kozlowska E, Van E, LJ, Griffin WST.; Human brain S100beta
and S100beta mRNA expression increases with age: pathogenic implications for Alzheimer's disease.
Neurobiol Aging 1996;17:359-363.
- Sheng JG, Zhou XQ, Mrak RE, Griffin WST.; Progressive neuronal injury associated with amyloid
plaque formation in Alzheimer disease. J Neuropathol Exp Neurol 1998;57:714-717.
- Sheng JG, Zhu
SG, Jones RA, Griffin WST, Mrak RE: Interleukin‑1 promotes
expression and phosphorylation of neurofilament and tau
proteins in vivo. Exp Neurol 163:388‑391, 2000.
- Souder E,
Terry TL, Mrak RE: Autopsy 101. Geriatric Nursing 24:330-337,
2003.
- Stanley LC, Mrak RE, Woody RC, Perrot LJ, Zhang SX, Marshak DR, Nelson SJ, Griffin WST.;
Glial cytokines as neuropathogenic factors in HIV infection: Pathogenic similarities to Alzheimer's disease.
J Neuropathol Exp Neurol 1994;53:231-8.
- Thal DR,
Schultz C, Botez G, Mrak RE, Griffin WST, Wiestler OD, Braak H,
Ghebremedhin E: Argyrophilic grain disease: Concurrent Alzheimer's
disease-related damage lowers the threshold for dementia Neuropathol
Applied Neurobiology (in press).
- Van Eldik LJ, Griffin WST.; S100beta expression in Alzheimer's disease: Relation to neuropathology
in brain regions. Biochim Biophys Acta 1994;1223:398-403.
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